METHOD AND DEVICE FOR AUTOMATED JOB FAILOVER

In an embodiment of the present disclosure, there is provided a method of managing multi data cluster failure. The method comprises scheduling one or more applications on a primary cluster and a secondary cluster, monitoring a status of the one or more applications scheduled in one cluster by the other data cluster, identifying the status of the applications of one cluster by the other cluster, updating the status of the one or more applications associated with each cluster on the distributed file system (DFS) of respective cluster, and generating output reports of the scheduled one or more applications. The method automatically converts the secondary data cluster to the primary cluster and vice-versa upon identifying the status of primary cluster as under failure or under maintenance during monitoring

Simulation of Cylindrical Resonator with Spiral Neck and Straight Neck to Attenuate the Low Frequency Noise of Muffler

This paper is concentrated for improving the transmission loss and reduces the low frequency noise level by development of Helmholtz Resonator within a limited space. The modified Helmholtz resonator, i.e. cylindrical resonator with spiral neck is used to occupy the small space. Introduction of spiral neck instead of straight neck with cylindrical cavity reduces the space of resonator. For first cut-off frequency (resonance frequency) the volume of resonator is fixed, so with the help of spiral neck its length increases, volume increases and its curvature effect is also helpful in the reduction of noise. The finite element analysis tool Comsol multiphysics is used to validate the result. The results shows interesting factor that resonator not only attenuate a particular low frequency noise as well it increases transmission loss with spiral neck. Helmholtz resonator with a spiral neck can achieve high sound reduction within a small space at low frequency

Common sources of radiations in a medical environment

Use of radiation is now a days so common in most of the tertiary care hospitals for diagnostic and therapeutic purpose. The ionizing radiation provides many benefits in both diagnostic as well as therapeutic interventions, but they are also potential harmful. Radiation risks, exposure and mitigation strategies should always be in mind while using to an individual (public, radiation worker, and patient) and the environment should not exceed the prescribed safe limits. Regular monitoring of hospital area and radiation workers is mandatory to assess the quality of radiation safety. This review article emphasis on radiation risks, exposure and prevention and treatment strategies

Anti-inflammatory activity of leaves of Michelia champaca investigated on acute inflammation induced rats

Natural products play a significant role in human health in relation to the prevention and treatment of inflammation conditions. Although not fully understood, several action mechanisms are proposed to explain in vivo inflammatory action. The aim of this study was to assay different extracts from leaves of Michelia champaca (Magnoliaceae) on carrageenan induced inflammation rat model. The results were analyzed by One Way Analysis of Variance (ANOVA). The ethanolic extract (200 mg/kg) was found to be highly significant (p < 0.0001) with maximum inhibition (60.99 %) at 3 h against to positive control group. The findings conclude that M. champaca leaves extract exhibits an anti-inflammatory activity in pro-inflammatory conditions.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Morphological Changes and Antihyperglycemic Effect of M. champaca Leaves Extract on Beta-cell in Alloxan Induced Diabetic Rats

Rapidly increasing diabetes mellitus is becoming a serious threat to mankind health in all parts of the world. The control of treatment depends upon the availability medicines without any side effects. Traditional anti-diabetic plants, which can counter the high cost and poor availability of the current medicines. So an attempt was made to study the beneficial effects of M. champaca leaves extracts on pancreas morphology of diabetic rat model. M. champaca leaf extracts (Ethanolic, Chloroform and Petroleum Ether) were administered at dose levels of 200 mg/kg body weight orally. A positive control and normal group received distilled water orally. Blood samples were collected from retro-orbital plexus of each rat and analyzed by GOD-POD test. After 21 days treatment among different extracts, the maximum reduction of serum glucose level showed significantly (

Targeted collapse regularized autoencoder for anomaly detection: black hole at the center

Autoencoders have been extensively used in the development of recent anomaly detection techniques. The premise of their application is based on the notion that after training the autoencoder on normal training data, anomalous inputs will exhibit a significant reconstruction error. Consequently, this enables a clear differentiation between normal and anomalous samples. In practice, however, it is observed that autoencoders can generalize beyond the normal class and achieve a small reconstruction error on some of the anomalous samples. To improve the performance, various techniques propose additional components and more sophisticated training procedures. In this work, we propose a remarkably straightforward alternative: instead of adding neural network components, involved computations, and cumbersome training, we complement the reconstruction loss with a computationally light term that regulates the norm of representations in the latent space. The simplicity of our approach minimizes the requirement for hyperparameter tuning and customization for new applications which, paired with its permissive data modality constraint, enhances the potential for successful adoption across a broad range of applications. We test the method on various visual and tabular benchmarks and demonstrate that the technique matches and frequently outperforms alternatives. We also provide a theoretical analysis and numerical simulations that help demonstrate the underlying process that unfolds during training and how it can help with anomaly detection. This mitigates the black-box nature of autoencoder-based anomaly detection algorithms and offers an avenue for further investigation of advantages, fail cases, and potential new directions.Comment: 16 pages, 4 figures, 4 table

Anti-inflammatory activity of leaves of Michelia champaca investigated on acute inflammation induced rats

Natural products play a significant role in human health in relation to the prevention and treatment of inflammation conditions. Although not fully understood, several action mechanisms are proposed to explain in vivo inflammatory action. The aim of this study was to assay different extracts from leaves of Michelia champaca (Magnoliaceae) on carrageenan induced inflammation rat model. The results were analyzed by One Way Analysis of Variance (ANOVA). The ethanolic extract (200 mg/kg) was found to be highly significant (p < 0.0001) with maximum inhibition (60.99 %) at 3 h against to positive control group. The findings conclude that M. champaca leaves extract exhibits an anti-inflammatory activity in pro-inflammatory conditions.Colegio de Farmacéuticos de la Provincia de Buenos Aire

The profile and treatment outcomes of the older (aged 60 years and above) tuberculosis patients in Tamilnadu, South India

Background: With changing demographic patterns in the context of a high tuberculosis (TB) burden country, like India, there is very little information on the clinical and demographic factors associated with poor treatment outcome in the sub-group of older TB patients. The study aimed to assess the proportion of older TB patients (60 years of age and more), to compare the type of TB and treatment outcomes between older TB patients and other TB patients (less than 60 years of age) and to describe the demographic and clinical characteristics of older TB patients and assess any associations with TB treatment outcomes. Methods: A retrospective cohort study involving a review of records from April to June 2011 in the 12 selected districts of Tamilnadu, India. Demographic, clinical and WHO defined disease classifications and treatment outcomes of all TB patients aged 60 years and above were extracted from TB registers maintained routinely by Revised National TB Control Program (RNTCP). Results: Older TB patients accounted for 14% of all TB patients, of whom 47% were new sputum positive. They had 38% higher risk of unfavourable treatment outcomes as compared to all other TB patients (Relative risk (RR)-1.4, 95% CI 1.2–1.6). Among older TB patients, the risk for unfavourable treatment outcomes was higher for those aged 70 years and more (RR 1.5, 95% CI 1.2–1.9), males (RR 1.5, 95% CI 1.0–2.1), re-treatment patients (RR 2.5, 95% CI 1.9–3.2) and those who received community-based Direct Observed Treatment (RR 1.4, 95% CI 1.1–1.9). Conclusion: Treatment outcomes were poor in older TB patients warranting special attention to this group – including routine assessment and recording of co-morbidities, a dedicated recording, reporting and monitoring of outcomes for this age-group and collaboration with National programme of non-communicable diseases for comprehensive management of co-morbidities

HIV Testing among Patients with Presumptive Tuberculosis: How Do We Implement in a Routine Programmatic Setting? Results of a Large Operational Research from India.

BACKGROUND: In March 2012, World Health Organization recommended that HIV testing should be offered to all patients with presumptive TB (previously called TB suspects). How this is best implemented and monitored in routine health care settings in India was not known. An operational research was conducted in Karnataka State (South India, population 64 million, accounts for 10% of India's HIV burden), to test processes and learn results and challenges of screening presumptive TB patients for HIV within routine health care settings. METHODS: In this cross-sectional study conducted between January-March 2012, all presumptive TB patients attending public sector sputum microscopy centres state-wide were offered HIV testing by the laboratory technician, and referred to the nearest public sector HIV counselling and testing services, usually within the same facility. The HIV status of the patients was recorded in the routine TB laboratory form and TB laboratory register. The laboratory register was compiled to obtain the number of presumptive TB patients whose HIV status was ascertained, and the number found HIV positive. Aggregate data on reasons for non-testing were compiled at district level. RESULTS: Overall, 115,308 patients with presumptive TB were examined for sputum smear microscopy at 645 microscopy centres state-wide. Of these, HIV status was ascertained for 62,847(55%) among whom 7,559(12%) were HIV-positive, and of these, 3,034(40%) were newly diagnosed. Reasons for non-testing were reported for 37,700(72%) of the 52,461 patients without HIV testing; non-availability of testing services at site of sputum collection was cited by health staff in 54% of respondents. Only 4% of patients opted out of HIV testing. CONCLUSION: Offering HIV testing routinely to presumptive TB patients detected large numbers of previously-undetected instances of HIV infection. Several operational challenges were noted which provide useful lessons for improving uptake of HIV testing in this important group

Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials

Background Heterogeneity is a major obstacle to developing effective treatments for patients with primary Sjögren's syndrome. We aimed to develop a robust method for stratification, exploiting heterogeneity in patient-reported symptoms, and to relate these differences to pathobiology and therapeutic response. Methods We did hierarchical cluster analysis using five common symptoms associated with primary Sjögren's syndrome (pain, fatigue, dryness, anxiety, and depression), followed by multinomial logistic regression to identify subgroups in the UK Primary Sjögren's Syndrome Registry (UKPSSR). We assessed clinical and biological differences between these subgroups, including transcriptional differences in peripheral blood. Patients from two independent validation cohorts in Norway and France were used to confirm patient stratification. Data from two phase 3 clinical trials were similarly stratified to assess the differences between subgroups in treatment response to hydroxychloroquine and rituximab. Findings In the UKPSSR cohort (n=608), we identified four subgroups: Low symptom burden (LSB), high symptom burden (HSB), dryness dominant with fatigue (DDF), and pain dominant with fatigue (PDF). Significant differences in peripheral blood lymphocyte counts, anti-SSA and anti-SSB antibody positivity, as well as serum IgG, κ-free light chain, β2-microglobulin, and CXCL13 concentrations were observed between these subgroups, along with differentially expressed transcriptomic modules in peripheral blood. Similar findings were observed in the independent validation cohorts (n=396). Reanalysis of trial data stratifying patients into these subgroups suggested a treatment effect with hydroxychloroquine in the HSB subgroup and with rituximab in the DDF subgroup compared with placebo. Interpretation Stratification on the basis of patient-reported symptoms of patients with primary Sjögren's syndrome revealed distinct pathobiological endotypes with distinct responses to immunomodulatory treatments. Our data have important implications for clinical management, trial design, and therapeutic development. Similar stratification approaches might be useful for patients with other chronic immune-mediated diseases. Funding UK Medical Research Council, British Sjogren's Syndrome Association, French Ministry of Health, Arthritis Research UK, Foundation for Research in Rheumatology